Ronald A. Hill Photo
Ronald A. Hill
University of Louisiana Monroe
Louisiana
Biography
Ronald A. Hill, B.S.Chem., Ph.D., is a native of central Ohio. He graduated from the University of Michigan in 1982 with a B.S.Chem. degree, completing an honors thesis project in mechanistic organic chemistry with Professor Peter A. S. Smith. He then spent 4-1/2 years engaged in analytical chemistry and biopharmaceutics R&D at the Upjohn Company in Kalamazoo, MI, followed by graduate study at The Ohio State University, where he completed a Ph.D. in Pharmacy, with emphases in synthetic medicinal and computational chemistry. His graduate research was directed by Professors Duane D. Miller and Jan K. Labanowski (Ohio Supercomputer Ctr.). In 1991, he established a research group at ULM, mainly engaged in areas of synthetic medicinal and bioanalytical chemistry. Historically, his research, funded at various times by the NIH and the AHA, focused mostly on projects related to the central nervous system, particularly the efficient delivery of small organic molecules to the CNS and their distribution, biotransformation, and actions therein. Over the years, he also collaborated extensively with investigators working in areas of pharmaceutics, toxicology, pharmacology, and clinical sciences, and also gained extensive acumen in molecular therapeutics design, molecular biopharmaceutics, and molecular toxicology. His more-recent educational duties at the Ph.D. and Pharm.D. levels, and ongoing research collaborations in areas including cancer and Alzheimer’s disease, has demanded even more breadth and depth of knowledge, especially in areas bridging early discovery science to clinical application. He also currently serves as a member of the Expert Panel for the Cosmetic Ingredient Review, a key safety assessment body for non-drug personal care products. He has served as major adviser for a number of M.S. and Ph.D. students, and on the graduate committees of now more than 60 others, all of whom have an admirable record of accomplishment in industry, government, or academia.
As a Speaker
International Conference on Chemistry in Drug Discovery & Designing
Conference Track Name : Drug Discovery and Development | Computer Aided Drug Design (CADD) | Medicinal Chemistry in Modern Drug Discovery | Drug Metabolism and Drug Designing
Title : null
Research Interests
Pharmaceutics, Molecular Toxicology, Pharmacology
Synthetic organic chemistry Past efforts have been directed towards making new (or commercially unavailable) compounds - most recently including certain xenobiotic biotransformation products (i.e., "metabolites"), novel amino acids and their derivatives, and various heterocycles - so that their biological activities can be studied. Heavy emphasis has also been placed on the synthesis of novel types of bioprecursors for improved delivery or targeting of medicinal substances to the brain. My laboratory and our institutional infrastructure is well equipped for state-of-the-art synthetic chemistry projects. Applied analytical/bioanalytical chemistry Our work has included the development and application of analytical methods, mainly by high performance liquid chromatography (HPLC) with various detection methods, and now including multi-stage mass spectroscopic (MSn) for: 1. Determining concentrations of bioprecursors, parent pharmacological agents ("parent drug"), or biotransformation products in complex biological matrices such as the brain, blood, tissues, or excreta. 2. The characterization of solution equilibria and chemical degradation pathways. Nuclear magnetic resonance (NMR) spectroscopy, as well as other spectroscopic methods, are brought to bear as required for these efforts.

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