Scientific Program

Day 1

KEYNOTE SPEAKERS
  • Studies on 2-(4-Methoxy/Methyl)-Phenyl – 3- Substituted quinazolin-4 (3H)-one analogs as potential antibacterial agents

    MAHSA University
    Malaysia
    Biography

    Gopal Natesan has completed his Doctoral degree (PhD) in Pharmaceutical Chemistry from Hamdard University (Jamia Hamdard) New Delhi, India in 2000 and currently serving as Professor in Medicinal Chemistry, in MAHSA University, Kuala Lumpur, Malaysia. and Director (Academic & Operation) MAHSA Prima International College, MAHSA Group, Malaysia. He has published >40 articles in indexed journals and presented >80 papers in conferences and received number of honors, recently received “Young Scientist Award” in 2013 and “Edward Kennedy Memorial Award” in 2017 for his high standards of research excellence in Science and Technology. He was invited speaker at international scientific meetings and conferences and serves as reviewer for several scientific international journals and also as Editorial/Advisory board of various journals.

    Abstract

    The development of antibiotic resistance in pathogenic microorganism is a global health concern due to the emergence of multidrug resistant organism (MDRO). It is essential to synthesize novel antimicrobial agents to deal with increased number of multidrug resistance organisms (MDRO) and limited antimicrobial agent. Literature survey showed that quinazolin-4(3H)-one possess varied biological activities and 2nd and 3rd positions are the target for substitution with other moieties. On the other hand, isatin and sulphanilamide pharmacophore also exhibits wide range of pharmacological activities especially significant antibacterial activity though competitive inhibition of dihydropteroate synthetase enzyme. Hence, it has thought worthwhile to study the effects of these pharmacophoric moieties in one molecule with the base of quinazolin-4(3H)-one nucleus for better the antibacterial activity. A series of mannich bases, 2-(substituted phenyl)-3-[1-(substituted amino methyl)-2-oxoindolin-3-ylideneamino] quinazolin-4-(3H)-one derivatives and 2-(4’-substitutedphenyl)-3-[(N-2-oxoindolin-3-ylidene)-4”-sulphonamidophenyl]-quinazolin-(3H)-one has synthesised. The title compound has synthesised from the intermediate schiff bases which is prepared by reacting 2-(substituted phenyl)-4H-benzo[d][1,3]-oxazin-4-one with hydrazine hydrate and the required benzoxazinone derivate has been prepared by reacting anthranilic acid with substituted benzoyl chloride. All the synthesised compounds structures were characterised by using H1 Nuclear Magnetic Resonance Spectroscopy. The intermediate schiff base and final mannich base compounds were evaluated for their antibacterial activity against Staphylococcus aureus, Bacillus cereus, Escherichia coli, and Pseudomonas aeruginosa at a concentration of 50 µg/mL and 100 µg/mL by agar well diffusion method using Norfloxacin (50 µg/mL) as standard drug. From the study, it has been observed that the sulphanilamide substituted derivatives did not showed any inhibition against all the organism whereas amino substituted shciff and mannich base showed significant degree of inhibition. Finally, it has been concluded that mannich base derivatives of amino substitution at 3rd position in quinazolinone nucleus exhibited a higher degree of inhibition and also superior in its antibacterial activity against gram positive bacteria S. aureus and B. cereus. Keywords - Quinazolin-4(3H)-one, Sulphanilamide, Isatin, Mannich, Schiff base, Antibacterial activity Biography Gopal Natesan has completed his Doctoral degree (PhD) in Pharmaceutical Chemistry from Hamdard University (Jamia Hamdard) New Delhi, India in 2000 and currently serving as Professor in Medicinal Chemistry, in MAHSA University, Kuala Lumpur, Malaysia. and Director (Academic & Operation) MAHSA Prima International College, MAHSA Group, Malaysia. He has published >40 articles in indexed journals and presented >80 papers in conferences and received number of honors, recently received “Young Scientist Award” in 2013 and “Edward Kennedy Memorial Award” in 2017 for his high standards of research excellence in Science and Technology. He was invited speaker at international scientific meetings and conferences and serves as reviewer for several scientific international journals and also as Editorial/Advisory board of various journals.

  • The NAFLD conundrum: How to distinguish NAFLD from NASH utilizing a novel biomarker without a liver biopsy

    Rush University, Chicago, Illinois, USA
    USA
    Biography

    David H, Van Thiel is a professor of medicine, a former president of the American Association for the study of liver disease and is widely recognized as one of the founding fathers if not, the father of medical liver transplantation worldwide. He attended Pomona College in Clairemont, California, and then entered Medical School at the University of California at Los Angeles graduating with honors in 1967. He has served as the chief of gastroenterology/hepatology at the University of Pittsburgh, Dir. of hepatology at Loyola University Chicago, and Rush University, Chicago. He is currently in private practice of gastroenterology and hepatology with an emphasis on hepatology, which accounts for 80-85% of his practice.

    Abstract

    NAFLD is a liver disease characterized by increased hepatic fat with a global prevalence of 25.24%. NASH is characterized as having varying degrees of fat and inflammation within the liver. Both can progress to cirrhosis and hepatocellular carcinoma. This progression is faster and occurs more frequently with NASH than NAFLD. The healthcare burden of NAFLD in terms of health care costs because of the number of hospital admissions per patient, the severity of the liver disease, liver disease mortality, and non-liver disease mortality with the progression of NAFLD to Nash with or without cirrhosis. Thus, it is important to distinguish between NAFLD and NASH. A host of combined hematologic and serologic measures using various algorithms have been used for this purpose with variable and only modest success. Bore recently, ultrasound assessments using transient or shear wave (SWE) have been used for this purpose with the latter having the advantage of estimating the hepatic fat content determined by the hepato-renal ratio (HRR). SWE is more available, cheaper, and less demanding in terms of time commitment and experience as compared to MRE which is only available at a few research centers. Aim: To identify a serologic marker that identifies those with NASH from those with NAFLD. Methods: A total of 105 patients were investigated using SWE utilizing an Aixplorer Ultimate Supersonic Image Shear Wave unit. 30 “normal” controls without fatty liver disease, 15 with NAFLD and 3 with NASH with all 3 groups being matched for the following factors, BMI, type 2 diabetes mellitus, hypertension, hyperlipidemia presence of clinical sleep apnea. Results: The only laboratory parameter that identified those with NASH as distinct from those with NAFLD was at the plasma level of leptin. Conclusion: The plasma level of leptin distinguish is individuals with NASH from those with or without. NAFLD Biography: Dr. Van Thiel graduated from the University of California at Los Angeles in medicine. He completed 2 years of postgraduate education at Cornell University Hospitals in New York City followed by 2 years at the NIH in Bethesda Maryland an additional 2 years at Boston University in medicine in gastroenterology. He completed a second year of gastroenterology/hepatology fellowship and joined the faculty at the University of Pittsburgh where he spent the next 20 years as Dir. of Gastroenterology and Hepatology, Medical Dir. of the Liver Transplant Program, and achieved the rank of professor of medicine and surgery. He served as the President of the AASLD. RSA and Midwest Federation of Clinical Research. He was critical to the development of 6 distinguished liver transplant programs in US serving as the Medical Dir. at each. He has published over 1100 peer reviewed manuscripts in gastroenterology, hepatology, endocrinology, as well as others. He was awarded the Albert Nelson Marquis Lifetime Achievement Award in 2017.

  • Surveillance and impact of occult hepatitis B virus, SEN virus and TT virus among hemodialysis patients with chronic hepatitis C virus infection in the Eastern Province of Egypt

    Zagazig University
    Egypt
    Biography

    Fatma Amer graduated from the Faculty of Medicine, Zagazig University, Egypt and got her MSc and PhD degrees from the same university. She is the past head of Medical Microbiology and Immunology in Zagazig Faculty of Medicine, Egypt and the past president of the Arab Alliance for the Prudent Use of Antimicrobials. Currently she is an emeritus professor in the same university, the president of Hepatitis Working Group/International Society of Chemotherapy and Infection and is a board member of the International Society for Infectious Diseases. She supervised and evaluated many MSc and PhD theses, and is a reviewer of manuscripts submitted for journals, conferences and international awards. She published numerous articles. She has been given many national, regional and international awards. Through fund raising and provision of technical assistance she was the first to introduce automated Microbiology Service in her university and participated in the establishment of the Molecular Biology Unit in the Medical Microbiology and Immunology Department. She introduced an MSc degree in Infection Control at her faculty. She developed two volumes of Infection Control books; the first of their kind in Egypt. She participated in conferences all over the world as organizer, chairperson and speaker.

    Abstract

    Egypt ranks the first as regards prevalence of hepatitis C virus infection. Many patients have concomitant diseases like kidney disorders which necessitate hemodialysis, a procedure posing risk of transmitting other hepatitis viral infections. Occult hepatitis B infection (OBI) is blood- borne and Torque teno virus (TTV) and SEN virus (mainly D and H genotypes) are tentatively linked to non-A-E hepatitis. The purpose of this study is the surveillance of OBI, SEN virus and TTV in chronic HCV (CHC) infected patients on maintenance hemodialysis in Sharkya Governorate, Egypt and to identify their impact. Three hundred and twenty- five patients were enrolled. They were divided into two groups. Group 1 (case patients; 130 HCV RNA positive) and Group 2 (controls; 195 HCV RNA negative patients). All patients’ data were recorded. Blood samples were collected before hemodialysis. Sera were tested for antibodies to hepatitis B core (HBc) and surface antigens (HBs) using ELISA. HBV, SEN virus-D and SEN virus-H and TTV DNAs were detected by polymerase chain reaction. The serum activity of alanine and aspartate aminotransferase were measured. Results were statistically analyzed. Positive anti-HBc antibodies and HBV DNA were identified in 73.1% and 50.8% of group 1, versus 36.4% and 22.6% of group 2 patients respectively (statistically significant). Significant elevation of aminotransferases was identified among group 1 than group 2 patients. SEN virus was identified in 15 (11.5) of group 1; 6 SEN-D and 9 SEN-H versus 16 (8.2%) of group 2 patients; all were SEN-D. TTV was identified in 38 (29%) of group 1 versus 53 (27%) of group 2 patients. The existence of neither SEN nor TTV had significant implications. Due to high occurrence of OBI in our locality, diagnosis is recommended before hemodialysis for CHC patients. No importance of SEN virus and TT viruses is identified.

  • Thailand’s legal and regulatory framework for foreign investments in agriculture

    PUGNATORIUS Ltd., Thailand
    Thailand
    Biography

    Dr. Ulrich Eder is a German senior lawyer (Rechtsanwalt) and Certified Tax Ad- visor (Steuerberater) living and working in Bangkok, Thailand since 2007. He is Managing Director of PUGNATORIUS Ltd., a highly accredited international law office in Bangkok, Thailand. PUGNATORIUS Ltd. advises on foreign direct investments in Thailand, real es- tate developments, international tax planning, infrastructure and energy invest- ments, fintech ventures. The law firm has particular experiences and know-how in the transaction support of foreign investments in agriculture, fishery and live- stock.

    Abstract

    Apart from bio-technology, an essential aspect of plant science is its practical realization under the local legislator and regulatory framework. These aspects are discussed and explained. The topics could be as follows: Foreigner legislation on business activities, work and land ownership in Thailand; licensing and approval requirements, work-flow and time-line; new developments on investment promotion by the Thailand Board of Investment on agriculture and farming-related science; and milestones of the legal project management for foreign investors in Thailand Biography Ulrich Eder is a German senior Lawyer (Rechtsanwalt) and certified Tax Advisor (Steuerberater), since 2007. He is Managing Director of PUGNATORIUS Ltd., a highly accredited international law office in Bangkok, Thailand.

Natural Products and Biogenesis
Speaker
  • Evaluation of attenuating effect of Cocos nucifera on cold restraint stress model in rats
    Speaker
    Dr. Shivakumar Hugar
    BLDEA’s SSM College of Pharmacy & Research Centre
    India
    Biography

    Dr. Shivakumar Hugar working as Professor and Head, Post Graduate Dept. of Pharmacology, BLDEA’s SSM College of Pharmacy & Research Centre, Vijayapur – 586103, Karnataka, India. He obtained Ph.D. degree from Kuvempu Univrsity, Shankaragatta, Shivamogga in the year 2007. He is having 21 years of experience in teaching and research. He guided 45 M. Pharm and 3 Ph.D. students and 01 student of Pharmacology specialization is pursing Ph.D. under his supervision. Published 56 research papers in national and international journals. Presented 09 oral and 55 posters in national and international conferences and got best research paper award for 3 oral presentations. Attended International conference organized by Master Skill University, Malaysia in the year 2011. Dr. Shivakumar Hugar was Board Of Studies (BOS) member in Pharmacy (UG) 2009 - 2011, Rajiv Gandhi University of Health Sciences (RGUHS), Bangalore. Currently he is member of BOS in Pharmacy (PG) and also faculty member of Pharmacy, RGUHS, Bangalore. He has received research grant from RGUHS, Bangalore. He is also an editorial board member and reviewer for the few reputed journals. Dr. Shivakumar Hugar has been received Shikshak Shri Award from chief justice & first vice president of Nepal. This event was organized by Indo-Nepal Antarrashtriya Samrasta Manch on account of teacher’s day on 5th September at Krishna Menon Bhavan, New Delhi. He was member of International Organizing Committee of 12th International congress of Ethnopharmacology, Jadavpur University, Kolkata, India, held on February 17-19, 2012. He was the poster evaluator for P4 conference jointly organized by KLE University & Manipal, held at Belagavi, Karnataka, India. He is life member of APTI, KSPC, American Botanical Council and ACP. He is an examiner for various universities and evaluated Ph.D. thesis of different universities.

    Abstract

    Objective Traditional practitioners commonly use herbal extracts and polyherbal formulation for the management of stress. Ranahamsa Rasayanaya, a polyherbal formulation which contains Cocos nucifera is one of the ingredients used in management of stress disorders. Hence, this research was undertaken to scientifically validate antistress effect of Cocos nucifera L. endocarp. Material and Methods The test extract was subjected for preliminary phytochemical investigation to detect the presence of type of phytoconstitutents. The anti-stress effect of graded doses (125, 250 and 500 mg/kg, b/w) of ethanolic extract of Cocos nucifera endocarp was evaluated using cold restraint stress model in rats. Its antistress potential was investigated by estimating various parameters such as hematology, serum biochemical markers such as glucose, cholesterol, triglycerides and blood urea nitrogen (BUN). The weight of organs (Liver, spleen and adrenal glands) of experimental animals and noradrenaline and serotonin contents of brain tissue of stressed rats also recorded. Withania somnifera (100 mg/kg) used as reference standard. Results and discussion Screening doses of test extract chosen based on the LD50 cut-off value. The results of preliminary phytochemical investigation of test extract reveal the presence of flavonoids and tannins. Ethanolic extract of Cocos nucifera endocarp at 250 mg and 500 mg/kg exhibited significant anti-stress property against cold restraint stress model, which was evident by significant attenuation of altered haematological, serum biochemical markers, organs weight and neurotransmitter levels of brain tissue. The result of 125 mg/kg of the test extract was found to statistically not-significant. Withania somnifera, reference standard drug demonstrated significant anti-stress effect. The observed significant antistress effect of plant extract could be attributed to the presence of flavonoids and tannins. Conclusion The findings of the present study justify the incorporation of Cocos nucifera in Ranahamsa Rasayanaya, a well-known classical Sri Lankan Rasayana drug used in the management of stress disorders. Keywords: Cocos nucifera, anti-stress, cold restraint stress.

Biomedicine and Pharmacotherapy
Speaker
  • Isolation and characterisation of bioactive compounds of medicinal plants reported to having adaptogenic properties
    Speaker
    Dr. shrikant kadam
    SVPM’s College of Pharmacy
    India
    Biography

    Shrikant Sambhajirao kadam working as a Assistant Professor in the Department of Pharmaceutical Chemistry, SVPM’s College of Pharmacy, Malegaon (Bk), Baramati, affiliated to Savitribai Phule Pune university, Pune, India. He has received M.Pharm degree from Shivaji University Kolhapur. He is having 11 years of teaching experience in biochemistry and pharmaceutical analysis. His area of research lies in the field of Pharmaceutics, Biotechnology and Analysis. He is a life member of Association of Pharmaceutical Teachers of India (APTI) and Registered Pharmacist of Maharashtra State Pharmacy council (MSPC), India.

    Abstract

    Plants biosynthesize numerous secondary metabolites possessing diverse chemical structures. Search of bioactive compound responsible to elicit adaptogenic effect has been herculean task. In the present study also, we have isolated the quercetin and gallic acid from methanolic extract of G. lucidum and gallic acid from methanolic extract of P. Senega. The preliminary TLC studies of MEGL and MEPS demonstrated presence of phenolic compounds. Therefore, for isolation of these phenolic compounds, methanol extract was fractionated by using Toluene: ethyl Acetate: Formic acid (v/v/v) (7:5:1) and characterized by spectral (UV, IR, 1HNMR and Mass) analysis. Fractions were separated by using column chromatographic separation. The obtained spectral data was compared with literature and showed the complete agreement of quercetine and gallic acid. The presence of these bioactive components could be responsible for the observed potential adaptogenic activity.

Pre-formulation and Product Development
Speaker
  • PHYTOCHEMICAL INVESTIGATION AND IN VITRO PRELIMINARY ANTIMITOTIC STUDIES ON ETHANOLIC EXTRACT (EtOH) OF AERIAL PARTS OF LEUCAS DIFFUSA.BENTH.
    Speaker
    Dr. Praveen Srikumar Polu
    MRM college of pharmacy
    India
    Biography

    Praveen SriKumar Polu is working as professor in the department of pharmaceutical analysis in MRM College of Pharmacy, Hyderabad. He has done the PhD in 2010 Awarded from Andhra University, Visakhapatnam, in Faculty of Pharmaceutical Sciences.

    Abstract

    Lucas Diffusa commonly known as Thumbai (Tamil) decumbent herb is widely distributed in Asian countries and some places in India. The objective of present study was to investigate the presence of various phytochemical constituents and preliminary antimitotic screening for ethanolic extract. The crude EtOH extract of aerial plant of Leucas diffusa were taken under phytochemical investigation revealed the presence of steroids, triterpenoids, flavanoids and carbohydrates. The extract was fractioned and isolated from n-Hexane, Ethylacetate, and Chloroform partitionates by using column chromatography and preparative TLC techniques. The IR spectra of the EtOH extract indicated the presence of OH, C=O, C-H, C-O-C and NH. Cytotoxic properties of plant extracts being developed for cancer treatment are usually evaluated by a variety of in vivo and in vitro tests carried out in animal or plant based models. In the present study we have evaluated the possibility of using plant model the germinating Mung beans (Vigna radiata), for rapid and inexpensive screening of extract exhibiting cytotoxic properties. The EtOH extract showed strong inhibitory effect on seed germination at 100µg/mL, 250µg/mL and 500µg/mL. Our study shows that germinating V. radiata beans could be used as a convenient model for the preliminary screening of drugs exhibiting cytotoxic properties.

Green and Sustainable Pharmacy Practice
Speaker
  • Evaluation of adaptogenic activity profile of G. Lucidum and P. Senega
    Speaker
    Dr. Vinod Shivajirao Pawar
    SVPM’s College of Pharmacy
    India
    Biography

    Dr. Vinod Shivajirao Pawar working as a Associate Professor in the Department of Pharmacology, SVPM’s College of Pharmacy, Malegaon (Bk), Baramati, affiliated to Savitribai Phule Pune university, Pune, India. He has received PhD degree Javaharlal Nehru Technological Ubiversity (JNTU), Hyderabad, India in the field of Pharmacology in 2014. He is having 13 years of teaching experience in Biotechnology, Pharmacology and Human Anatomy & Physiology. His area of research lies in the field of preclinical pharmacology, endocrinal pharmacology and ethnopharmacology. Dr. Vinod Shivajirao Pawar had worked on research projects funded by SPPU. He has several research publications/presentations to date in national and international journals/conferences of high profile. He had received “Gold Medal” Award for best research paper on “Adaptogenic (Antistress) Activity of Methanolic Extract of Ganoderma lucidum Against Physical and Hypoxic Stress in Mice” International conference on Advancement in Health Sciences, organized by Masterskill University College of Health Sciences, Port Dickson, Malaysia. He is appointed as nominee of CECSEA, Ministry of Environment, Forest & Climate Change, Govt. of India. He is a life member of Association of Pharmaceutical Teachers of India (APTI) and Registered Pharmacist of Maharashtra State Pharmacy council (MSPC), India.

    Abstract

    Lucas Diffusa commonly known as Thumbai (Tamil) decumbent herb is widely distributed in Asian countries and some places in India. The objective of present study was to investigate the presence of various phytochemical constituents and preliminary antimitotic screening for ethanolic extract. The crude EtOH extract of aerial plant of Leucas diffusa were taken under phytochemical investigation revealed the presence of steroids, triterpenoids, flavanoids and carbohydrates. The extract was fractioned and isolated from n-Hexane, Ethylacetate, and Chloroform partitionates by using column chromatography and preparative TLC techniques. The IR spectra of the EtOH extract indicated the presence of OH, C=O, C-H, C-O-C and NH. Cytotoxic properties of plant extracts being developed for cancer treatment are usually evaluated by a variety of in vivo and in vitro tests carried out in animal or plant based models. In the present study we have evaluated the possibility of using plant model the germinating Mung beans (Vigna radiata), for rapid and inexpensive screening of extract exhibiting cytotoxic properties. The EtOH extract showed strong inhibitory effect on seed germination at 100µg/mL, 250µg/mL and 500µg/mL. Our study shows that germinating V. radiata beans could be used as a convenient model for the preliminary screening of drugs exhibiting cytotoxic properties.

Vaccine Drug Delivery System
Speaker
  • Evaluation of adaptogenic activity of Luffa cylindrica leaves extract
    Speaker
    Dr. Nanjappaiah H.M.
    BLDEA’s SSM College of Pharmacy & Research Centre
    India
    Biography

    Dr. Nanjappaiah H.M. is working as Associate Professor in the Department of Pharmacology, BLDEA’s SSM College of Pharmacy and Research Centre, Vijayapur, Karnataka, India. He obtained Doctor of Philosophy (Ph.D.) in Pharmacology under Pharmacy Faculty by Rajiv Gandhi University of Health sciences, Bangalore, Karnataka, India in the year Jan 2018. He received a research grant as Seed Money to Young Scientists for Research (SMYSR) from Vision Group on Science and Technology, Govt. of Karnataka, Bangalore in the year 2012-13. He published 20 research articles in various national and international journals and presented 30 posters 05 oral presentations in various conferences. Presently guiding 02 M Pharm Pharmacology students. He is member of Board Of Studies in Pharmacy (Doctor of Pharmacy), Rajiv Gandhi University of Health Sciences, Bangalore. He is life member of Association of Pharmaceutical Teachers of India and Karnataka State Pharmacy Council.

    Abstract

    Objective: To investigate adaptogenic activity of ethanolic extract of Luffa cylindrica leaves (EELCL). Methods: In the present study adaptogenic activity was screened against anoxia tolerance, swimming endurance and cold restraint stress models. In anoxia tolerance test, the mean time of appearing first convulsion in mice was taken as end point to determine the time of anoxia. In swimming endurance test, the mean time of swimming performance was recorded. The end point taken was when the animals started drowning and remain at the bottom of swimming tank for 10 sec. Estimation of biochemical parameters such as serum glucose, cholesterol, triglycerides and BUN and also weight of organs (Liver, adrenal glands, spleen and testes) were measured in cold restraint stress model. Results: Effect of EELCL on anoxia stress tolerance time in mice: In the anoxic stress tolerance test, the time taken for the mice to exhibit clonic convulsions was considered as the end point. The graded doses (50, 100, 200 mg/kg) of the test extract demonstrated dose and duration dependent significant delay in clonic convulsions on 7th, 14th and 21st day compared to control group received vehicle only. The lower dose of the test extract (50 mg/kg) did prolong the clonic convulsions at the end of 1st and 2nd week, but the results found statistically not significant. Antistress effect of the higher dose (200 mg/kg) of the test extract was found closer to that of the standard drug, Withania somnifera. Effect of EELCL on swimming endurance test in mice: There was dose dependent significant increase in swimming performance time monitored in mice pretreated with EELCL at graded doses (50, 100 and 200 mg/kg) for seven days. The percentage increase in swimming performance time was found to be 55 to 89. However, the effect of test extract on swimming performance time was found to be less potent than the reference standard drug, Withania somnifera. Effect of EELCL on biochemical parameters in cold restraint stress: Cold restraint stress adversely affected the serum concentration of various biochemical parameters. The induction of cold restraint stress significantly elevated the serum cholesterol, triglycerides, BUN and glucose levels in stress control rats compared to normal control group. Animals pretreated for ten days with test extract at different dose levels (50, 100, 200 mg/kg) showed significant and dose dependent fall in all the biochemical parameters, as compared to the stress control animals. Effect of EELCL on organs weight in cold restraint stress: Cold stress significantly increased the weight of liver, adrenal glands and decreased the testes and spleen weight. Ten days pretreatment with graded doses of EELCL significantly and dose dependently ameliorated the cold stress induced altered organs weight. Conclusion: In conclusion, the findings from the present study suggest that 70% hydro alcoholic leaf extract of Luffa cylindrica demonstrated increased resistance against different aversive stimuli in a nonspecific manner thus the test extract could possesses adaptogenic – anti-stress property.

Medicine Development and Safety Testing
Speaker
  • PHARMACOKINETIC DETERMINATION ATENOLOL ENANTIOMER IN RABBIT PLASMA BY REVERSE PHASE UFLC TECHNIQUE
    Speaker
    Dr. BM Gurupadayya
    JSS College of Pharmacy, JSS Academy of Higher Education & Research
    India
    Biography

    Dr BM Gurupadayya working as a Professor in the Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysore, India. He has received PhD degree from Kuvempu University, Shimoga, India in the field of Medicinal Chemistry in 2006. His area of research lies in the field of analytical/bioanalytical method development of drugs and pharmaceutical formulations. He is currently working on stereospecific separation and pharmacokinetic properties of chiral drugs in biological fluids. Dr.BM Gurupadayya had worked on research projects funded by government agencies viz. UGC, AICTE and VGST, DST. Presently 7 research scholars are completed their PhD degree under his supervision. In addition he has successfully guided more than 36 masters’ degree students in the field of pharmaceutical analysis. He has several research publications to date in national and international journals of high profile. He had received Dr. PD Sethi Annual Award for best research paper on application of TLC/HPTLC in pharmaceutical analysis, Sipra Innovative Pharma Research Award and best oral presentation award for title of “New chiral normal phase UFLC method for determination of venlafaxine hydrochloride enantiomers in pharmaceutical formulations” in the national conference of APTICON-2016. He is a life member of Association of Pharmaceutical Teachers of India (APTI), India Pharmaceutical Association (IPA) and Pharmacist of Karnataka State Pharmacy council, India.

    Abstract

    The present work describes the pharmacokinetic profile of (R)- and (S)- Atenolol (ATL) enantiomer in rabbits using rapid and selective liquid chromatography with liquid-liquid extraction (LLE) method. The ATL enantiomers were extracted from plasma by means of LLE using and were analyzed on a Lux cellulose i5 segment (150×4.6 mm, 5µ) column with ultraviolet detection at 225 nm. Atenolol enantiomers indicated great determination with a retention time (tR) of 2.7 min and 3.10 min individually. The lower limit of quantification of the ATL enantiomers in plasma was 2 µg/ml. The validated method was successfully applied to chiral pharmacokinetic studies of oral administration of racemic ATL to rabbits. (S)-ATL showed almost similar AUC, Tmax, and Cmax and same half-life compared (R)-ATL, indicating similar bioavailability of the both isomer. Key words: Atenolol, Enantioselective, USFDA Guidelines, Rabbit Plasma, RP-UFLC.

Day 2

KEYNOTE SPEAKERS
  • Bioremediation of metal contaminated environment: A review

    Amity Institute of Biotechnology
    India
    Biography

    S M Paul Khurana earned his PhD in 1969 at the age of 23 years from University of Gorakhpur, India. He was the Director of CPRI, Shimla, VC, RD University, Jabalpur (MP, India), Director, Biotechnology, & Dean, Sci, Eng. & Tech Faculty, Amity Univ, Gurgaon. Currently he is working as professor of Biotech/Head USIC. He has over 215 research publications that have been cited almost 2150 times, and his publication H-index is 21. He has been Chief Editor for Indian Phytopathology. J Indian Potato Assoc, Indian Virology and member of many National & Int’l Journals.

    Abstract

    Metal contaminants cause specific toxicity at higher concentration in environment, by altering the nucleic acids conformation, proteins and interference with oxidative phosphorylation. The soil sources of heavy metals are metal-rich mine tailings, electroplating, gas exhaust, energy and fuel production, weathering of minerals, erosion, volcanic activity, downwash from power lines, intensive agriculture use of pesticides, phosphate fertilizer discharge, biosolids (e.g., livestock manures, composts, and municipal sewage sludge), and sludge dumping. Managing these wastes due to urbanization/population explosion in developing countries is a challenge due to toxins released. Dumping industrial wastes affects all living creatures, losing biodiversity. Biotechnological approaches as disparaging bioaugmentation, land farming, bio pilling is used to degrade the heavy metals. Their toxic effect on kidneys, nervous system, may lead to the symptoms of mental disorder, weakness, headaches, abdominal cramps, diarrhea, anemia and in certain cases even permanent damage of the organelles. Streptomyces sp bioremediated heavy metals from waste water to a great extent, viz Mn+2 :79, Pb+2:32, Fe+2: 24, Cr+2::22, Cu+2:16, Cd+2 :12, Ni+2: 12 and Zn+2:11% respectively. Biotechnological interventions will be reviewed and discussed at length during the presentation.

  • Pattern of adverse drug reactions in a tertiary care medical college and hospital

    Dr. Rajendra Prasad Government Medical College Kangra
    India
    Biography

    Doctor Dinesh Kansal working as an professor and HOD in the Department of Pharmacology at Dr. Rajendra prasad Government Medical College Kangra.He has completed his graduation M.B.B.S in the year 1983 at Himachal Pradesh University, Shimla H.P. He has done his masters degree in the year 1998 at Himachal Pradesh University, Shimla H.P. He has teaching experience from past 28 years. His area of interest in Neuro pharmacology, Experimental and Analytical Pharmacology,Clinical Pharmacology,Pharmacovigilance. He has published the 28 Research Papers in International / National Journals.He got an award Bharat Vidya Rattan award by International Business Council, New Delhi. He has Organized CME on Pharmacovigilance at Dr. RPGMC Kangra at Tanda in October 2013.Organized CME on Haemovigilance at Dr. RPGMC Kangra at Tanda in April 2014. He was invited as an Chairperson at 46th Annual Conference of Indian Pharmacological Society on 16th to 18th December, 2013 at Bengaluru. Chairperson at 2nd International & 5th National Conference of Indian Society for Rational Pharmacotherapeutics on 30th January to 1st Feburary, 2014 at DMC Ludhiana. Chairperson at International Conference of Pharmacology & Drug Discovery on “Pharmacology for Future: Towards Translational Approach for Next Generation Pharmacologists” at Maharaja Agrasain University. He was coordinated in Coordinator of Adverse drug reaction monitoring Centre, Pharmacovigilance Program of India, Indian Pharmacopoeia Commission, Ghaziabad U.P under the aegis of Ministry of Health and Family Welfare, Government of India. Chairperson Institutional Prescription audit Committee. Chairperson of Institutional Animal Ethics Committee of Dr. RPGMC Tanda H.P, Editor in chief Indian Journal of Pharmacy and Pharmacology. Member Institutional Disciplinary Committee. He was an Research Guidant to M.D Students Since 2011.

    Abstract

    Background: Adverse drug events can lead to admission in hospital, prolongation of hospitalisation, increase in investigation and treatment costs, deformities, danger to life and even death. Methods: A retrospective analytical study was conducted of adverse drug reaction (ADR) reports collected in our ADR Monitoring Centre established in Pharmacology Department under the Aegis of Indian Pharmacopoeia Commission (IPC) Ghaziabad (MINISTRY OF Health & Family Welfare, Govt. of India). Data pertained to the period from March 2015 to March, 2018. Results: A total of 1059 reports were analysed. 568(54%) patients were females and 491(46%) were males. The majority of ADRs were due to Cancer Chemotherapy agents in 493(46.5%) patients, followed by 182(17%) in HIV patients, and 162(15%) in T.B. patients. 726(68.5%) patients recovered completely at the time filling up of form, 328(31%) were recovering and 5 patients died. 3 deaths were of snake bitecases and 2 deaths were of MDR TB cases. Conclusion: Awareness and timely intervention in case of ADR can save many precious lives.

Plant Genomics
Plant Nutritional Genomics
Chair
Plant Tissue Culture
Chair
Plant Synthetic Biology and Transcriptome
Chair

Mail us at

Program Manager
sofia.marry@alliedscholars.com
Sponsorship/Exhibitor Opportunity
sponsors@alliedscholars.com
General Enquiry
info@alliedscholars.com
More details about sponsorship:sponsors@alliedacademies.com

Terms and Conditions

Responsibility

The organizers holds no responsibilities or liabilities of the personal articles of attendees at the venue against any kind of theft, lost, damage, due to any reason whatsoever. Delegates are entirely responsible for the safety of their own belongings.

 

Insurance

No insurance, of any kind, is included along with the registration in any of the events of the organization.

 

Transportation

Please note that transportation and parking is the responsibility of the registrant, Allied Academies will not be liable for any actions howsoever related to transportation and parking.

 

Press/Media

Press permission must be obtained from Allied Academies Conference Organizing Committee prior to the event. The press will not quote speakers or delegates unless they have obtained their approval in writing. The Allied Academies is an objective third-party nonprofit organization and this conference is not associated with any commercial meeting company.

 

Requesting an Invitation Letter

For security purposes, letter of invitation will be sent only to those individuals who had registered for the conference after payment of complete registration fee. Once registration is complete, please contact pharmaceutical@alliedmeetings.com to request for a personalized letter of invitation, if not received until one month before the scheduled date of event.

All the bank charges applicable during refund will be deducted from the account of participant.

 

Cancellation Policy

All cancellations or modifications of registration must be made in writing to finance@alliedacademies.com

 

If, due to any reason, Allied academies postpone an event on the scheduled date, the participant is eligible for a credit of 100% of the registration fee paid. This credit shall only be used for another event organized by Allied academies within period of one year from the date of rescheduling.

 

Postponement of event

If, due to any reason, Allied academies postpone an event and the participant is unable or unwilling to attend the conference on rescheduled dates, he/she is eligible for a credit of 100% of the registration fee paid. This credit shall only be used for another event organized by Allied academies within period of one year from the date of rescheduling.

 

Transfer of registration

All registrations, after payment of complete registration fee, are transferable to other persons from the same organization, if in case the person is unable to attend the event. Request for transfer of registration must be made by the registered person in writing to finance@alliedacademies.com. Details must include the full name of replaced new registrant, their title, contact phone number and email address. All other registration details will be assigned to the new person unless otherwise specified.

Registration can be transferred to one conference to another conference of Allied academies if the person is unable to attend one of conferences.

However, Registration cannot be transferred if intimated within 14 days of respective conference.

The transferred registrations will not be eligible for Refund.

This cancellation policy was last updated on April 04, 2015.

 

Visa Information

Keeping in view of increased security measures, we would like to request all the participants to apply for Visa as soon as possible.

Allied academies will not directly contact embassies and consulates on behalf of visa applicants. All delegates or invitees should apply for Business Visa only.

Important note for failed visa applications: Visa issues are not covered under the cancellation policy of Allied academies, including the inability to obtain a visa.

 

Refund Policy:

If the registrant is unable to attend, and is not in a position to transfer his/her participation to another person or event, then the following refund policies apply:

Keeping in view of advance payments towards Venue, Printing, Shipping, Hotels and other overhead charges, following Refund Policy Orders are available:

  • Before 60 days of the conference: Eligible for Full Refund after deduction of $100 towards service Fee.
  • Within 60-30 days of Conference: Eligible for 50% of payment Refund
  • Within 30 days of Conference: Not eligible for Refund
  • E-Poster Payments will not be refunded.

 

Accommodation Cancellation Policy:

Accommodation Service Providers (Hotels) have their own cancellation policies which are applicable when cancellations are made less than 30 days prior to arrival. If in case the registrant wishes to cancel or amend the accommodation, he/ she is expected to inform the organizing authorities on a prior basis. Allied academies will advise the registrant to ensure complete awareness about the cancellation policy of your accommodation provider, prior to cancellation or modification of their booking.

Authorization Policy


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