Stem cell congress 2018 extends a heartiest welcome to proficient delegates, scientists, professors, students, young researchers, business executives, scholars, chemists and professionals across the globe to be a part of 'International conference on stem cells and tissue regeneration", during June 04-05, 2018, to be held at Osaka, Japan. Keynote presentations, exhibitions, oral talks and poster presentations outlines the key attractions of the conference on the theme "Stem cells : A customized approach for well-being.
Track 1: Stem cells: An insight
Stem cells are undifferentiated cells found in multicellular organisms which divide through mitosis and differentiate into specialized cells. The two classical properties of stem cells which allows them to differentiate into almost any kind of body cell, are, self- renewal and potency. Due to their potential role in alternative therapies, stem cells are a topic of extensive research medical sciences.
· Collecting human embryonic stem cells
· Growth factors in stem cell differentiation
· In-vitro culturing of stem cells
· Future prospects of somatic stem cells
Track 2: Molecular basis of regeneration
Regeneration is a universal phenomenon in nature by which lost cells, tissues or body parts are replaced or restored in an organism as a general process of growth. During this process, adult stem cells or progenitor cells proliferate and differentiate to compensate the loss. The ability to regenerate depends upon the potency of any cell, categorized under totipotent, pluripotent, multi- potent, omnipotent and uni-potent.
· Hematopoietic stem cells for blood disorders
· Mesenchymal stem cells for neuromuscular disorders
· Directed differentiation of somatic stem cells
Track 3: The science of tissue engineering
Tissue engineering is a multi-disciplinary science involving the principles of cell biology, engineering and material sciences to replace or restore biological tissues which perform a specific function with a better framework. It is an act of combining the cells of construct, scaffold and growth factors into a functional tissue. The feasibility of bone-marrow derived mesenchymal stem cells, cardiac valves, auricular cartilage reconstruction, etc. explains the enormous potential of this relatively new field in biomedical sciences.
· Artificial cardiac valves
· Extracellular matrix analogues
· Auricular cartilage reconstruction
· Biomaterials and biopolymers for tissue engineering
· Hydrogels for tissue engineering
· Dermal tissue engineering
Track 4: Concept of tissue regeneration and regenerative medicine
Not all tissues in the body are devised to regenerate after damage. Tissue regeneration emphasises on the science of regenerating functional body parts for medical treatments aimed at restoring normal body functions after disease, trauma and congenital issues. It gives rise to a translational field of regenerative medicine, came into existence two decades ago, and, harnesses the principles of molecular biology and tissue engineering. Use of stem cells is an integral part of regenerative medicine which emphasises on the possibility of culturing tissues and organs in-vitro and their implantation into the subject.
· Antibiotic based tissue regeneration scaffolds
· Prevention of intervertebral discs degeneration
· Ligament regeneration with biomechanics
· Osteoarthritis and knee joint replacement
· Artificial pacemakers
· Organ regeneration and artificial pancreas.
Track 5: Current era of stem cell research
Stem cell research laid a foundation of basic scientific perception about the development of whole organism from a unicellular entity or single cell itself. These cells are collected from few days old embryo, amniotic fluid or many other tissues, like, bone marrow and cultured in the laboratory under biological conditions. Stem cell research is an aid of utmost important to serve as a model for genetic disorders, study DNA repair mechanisms or to design replacement therapies for practically immedicable chronic conditions.
· Bone marrow transplant for adenosine deaminase deficiency (ADA)
· Clinical research in stem cell therapy
· Stem cells in organ development
· Immune suppression of xenografts
· Induction of cancer by stem cells
Track 6: Stem cell therapeutics
Stem cell therapy is aimed at treating numerous degenerative, hematopoietic and neuromuscular disorders, nearly 80 in number which cannot be treated with conventional methods. Bone marrow transplantation for blood disorders like, leukaemia is the most celebrated application of stem cell therapy, other than skin tissue grafting and implantation. This new approach in medical biology is inclined at maximizing the quality of life by reducing the adversities of chronic disorders such as cancer and genetic diseases.
· Myelogenous or lymphocytic leukemia
· SCID-X1 stem cell therapy
· Type-I diabetes
· Alzheimer’s disease
· Parkinson’s disease
· Spinal cord trauma
Track 7: Nano-biotechnology in regenerative medicine
Nano-biotechnology in medical sciences renders some highly convincible outcomes in which few are only envisioned, while others are at different phases of clinical trials or already in practice. Nano-biotechnology in regenerative medicine includes utilization of nano-particles which are being designed now-a-days and envisioned research that involves usage of nano-robots to imply changes at cellular and molecular level. Recently, it is being used for drug-delivery, thermo- and laser therapy for cancer treatment. Particles are designed in such a way that they are easily being recognized by surface receptors of target cells to ensure direct treatment and least possible damage to unaffected cells. This technology is also exploited for detection of diseases in initial phases for devising an effective therapy.
· Pharmaceutical nanotechnology
· Nanoparticle based anti-bacterial scaffolds
· Nanoparticle based drug-delivery systems
· Nanotheranostic systems and their applications
· Nano-robots in therapy
· Nanoparticle imaging for disease diagnosis
Track 8: Bio-informatics in stem cell research
Bio-informatics deals with the development of algorithms and databases to manage, predict and analyse biological data. In-silico analysis of small molecules as a potential drug delivery target is a preliminary step in drug designing to ensure maximum efficacy. Self- learning algorithms, like, artificial neural network, are important tool for vaccine designing. Computational biology along with bio-informatics is a vast domain incorporating consolidated facts from computer science engineering, animation, ecology, genomics, immunology, neuroscience, biochemistry and biophysics which can be used as pre-knowledge tools for designing stem cell therapies.
· In-silico vaccine designing
· Molecular docking for drug delivery
· Designing therapies for genetic disorders
Track 9: Cancer stem cells
Certain immortal cells within the tumour are capable of proliferating into all other types of cancer cells. These cells, known as cancer stem cells, are the primary targets of cancer biologist and oncologist for treatment of various tumours, even though they are fairly resistant to chemotherapy and radiotherapy. Approaches have been made to exploit the property of these cells to develop immortal cell lines for production of drugs and cytokines relevant to medical use, but, a lot more understanding is required before bringing the results in practice.
· Prognostic and diagnostic biomarkers of cancer stem cells
· Targeting tumorigenic cells
· Pharmaceutical applications of cancer stem cells
· CSC drug resistance
· Cancer antigens as immunotherapy targets
Track 10: Reprograming of stem cells
The discovery of Induced pluripotent stem cells emphasises on reprograming of any adult differentiated cells into stem cells by genetic modification under precisely controlled laboratory conditions. Reprograming of cells is supposed to presage revolution in both, medical and biological research and allows modelling and analysis of human diseases and cell cytotoxicity by drugs. The technique is still in its growing phase and requires a great deal of extensive research and approval from authorities for further trials.
· Induced pluripotent stem cells
· Disease modelling using iPSC for Muscular Dystrophy
· Regeneration of RBCs
· Wiskott-Aldrich syndrome
Track 11: Stem cell banking
Umbilical cord blood is highly enriched with pluripotent stem cells which are considered lifesaving in later stages of life as they can treat a host of disorders. Cord blood stem cells are used to target blood disorders, immune deficiencies and rare metabolic disorders, including leukaemia, Krabbe disease, aplastic anaemia, non-Hodgkin’s lymphoma and Hodgkin’s lymphoma, sickle-cell anaemia and thalassemia, with least chances of rejection by the body. Cord blood preservation of new born babies, also termed as, stem cell banking, in public or family banks, is gaining a lot of awareness among people as it holds promise for future well-being.
· Global market of cord blood preservation
· Clinical aspects of stem cell banking
Track 12: Genome editing in stem cells
The development of targeted genome editing technique using custom-engineered sequence-specific nucleases (including CRISPR/Cas9) allowed genetic changes with greater precision. This technique has a widespread application in reprograming of stem cells to study disease outcomes. The rapid evolution of these two techniques over years and their relationship with one another has paved a way for understanding cellular interactions and regulation of transcription at molecular level with appreciable efficiency and flexibility.
· CRISPR/Cas9 in genome editing
· Genome editing for designer babies
· DNA repair in stem cells
· Generation of animal models by genome editing
· Targeting genetic diseases by genome editing in stem cells
Track 13: Future prospects of stem cell research and regenerative medicine
The extent of research in the field of stem cells has grown manifolds over the past few decades. Use of adult stem cells in alternate disease therapies is the new promising approach with striking progress in regenerative medicine. With the emergence of new stem cell pharmaceutical products for disease control, therapeutic potential of stem cells and tissue regeneration seems boundless.
· Vision improvement
· Tooth regeneration
· Gene therapy for blood transfusion
· Bone regeneration
· Skin rejuvenation
Track 14: Bioethical issues and challenges in stem cell research
Stem cells and their applications in tissue regeneration comes with a few interesting controversies regarding the bioethical issues involved in stem cell research. The collection of somatic stem cells from the human foetuses and umbilical cords is the most extreme controversy so far. Other issues involves the potential of stem cells to induce a tumour in the body and use of embryos which are only few days old. Human embryo cloning was suggested as an alternative to this situation which was highly criticized by the ethical groups. Currently, lack of stem-cell markers and in-vitro systems for manipulation, also hinders the research and makes it a daunting task.