Flavio Maina has completed his PhD at the University of Turin (Italy) and postdoctoral studies at EMBL (Germany). He is group leader at the IBDM since 2000. He was recruited at the CNRS as CR1 in 2000, got the HDR in 2005, then promoted DR2 in 2010 and DR1 in 2015. He has published more than 50 papers in reputed journals. His team studies how qualitative and/or quantitative receptor tyrosine kinase (RTK) signaling changes lead to diversified cell behaviors. By applying integrative approaches, the team explores vulnerability versus resilience of cells to signaling fluctuations, and how cell plasticity intercalates such signaling changes. Most of team projects are based on interdisciplinary approaches. Strong scientific team competences include those on: RTK signaling, cell signaling mechanisms, mouse genetics and development, gene targeting, stem cell biology, and liver cancer. Research is performed by intercalating phenotypic and mechanistic studies in cultured cells and in vivo.