Scientific Program

Day 1

KEYNOTE SPEAKERS
  • Solving the mystery of autism spectrum disorders from a pediatric school neuropsychological perspective

    Full Professor of Psychology Curry College,President and Owner of NEALAC Clinic
    USA
    Biography

    Dr. Leonard-Zabel is a full professor of Psychology at Curry College in Massachusetts, USA. She is president of private clinic specializing in international School Neuropsychology and Clinical Forensic Counseling. She holds diplomat and fellow certifications in the field of Neuropsychology, Forensics, Autism, Psychotherapy, Addictions, CBT, Disability Analysis, and Homeland Security. She was recognized in the American Psychological Association-Monitor on Psychology Journal under the personality and achievement section. This year she was awarded the Distinguished Leadership Circle of Directors from the American Board of Disability Analysts and the title of Honorary Founding Faculty Member for the American College of Disability Analysts. She serves on the Learning Disabilities Worldwide Congress-Board of Directors. She was awarded the Curry College Excellence in Teaching 'Researcher of the Year' and 'Person of the Year' from Curry College acknowledging excellence in teaching, mentorship, leadership and community service. Recently, she was awarded the Jerrold Simon Award for Distinguished Lifetime Career Achievement from both the American Board of Disability Analysts and the American Board of Medical Psychotherapists and Psychodiagnosticians of which she is the third recipent to ever receive the award from both organizations.

    Abstract

    Goal: Children and youth are being diagnosed on a daily-basis with Autism Spectrum Disorders (ASD). This presentation will explore autism spectrum disorders from a Pediatric School Neuropsychological approach. A comprehensive assessment is a necessary step in the overall planning for students with Autism Spectrum Disorders (ASD). However, children and youth with ASD are likely to present with unique challenges and issues during the formal neuropsychological assessment, which may impact the successful completion of the evaluation process and the usefulness of the assessment data. Since instructional programming is considered on information regarding a child and youth’s current levels of performance and identification of educational needs, accurate and useful assessment data is of utmost importance to the individual’s educational adjustment and personal success. The goal of this presentation is to provide an understanding of ASD from a pediatric school neuropsychological and brain-based perspective involving the assessment process. Objective ?Autism Spectrum Disorders (ASD) defined via the Diagnostic and Statistic Manual of Mental Disorders (DSM-5) from an educational/clinical perspective. ?Informal ASD Screening approaches to review pathognomonic neuropsychological signs. ?Formal assessment of ASD from an Integrated Pediatric School Neuropsychological Model ?Neuropsychological strengths/weaknesses associated with ASD to aid with educational planning. As a result of addressing the above objectives, professionals will learn a "Best Practices" approach to Pediatric School Neuropsychological Assessment of Autism Spectrum Disorders.

  • Lithium utilizes hidden cellular ‘Fail-Safe-Mechanisms

    South Birmingham & Solihull Mental Health NHS Foundation Trust
    United Kingdom
    Biography

    Arthur Ernst van Woerkom is a general adult psychiatrist. Completed his training in natural sciences for medicine at Trinity Hall, and Addenbrookes, Cambridge), and he have a long standing interest in the biochemistry of mood disorders, schizophrenia and psychosis. Many years ago, before he started working in the field of psychiatry, he proposed that major hallucinogens such as LSD and mescaline act in key part by disrupting the fine structure of consciousness by causing the collapse of tubulin and actin related cytoskeletal mechanisms. For a few years he was in an NHS funded research fellowship at the department of psychiatry with Prof Martin Roth. For a time, he was an honory senior clinical lecturer in psychiatry in Birmingham.

    Abstract

    A new unified model for Lithium’s mode of therapeutic action has recently been proposed. Lithium’s many protective actions provide evidence for the existence of a set of low-cell [Mg++] sensitive, cell-protection systems. To survive in conditions associated with a very low cell [Mg++], (neuronal) cells will require ‘Fail-Safe’ mechanisms, as below a critically low intracellular [Mg++], many Mg++ requiring systems risk grinding to a halt. This latent vulnerability implies the existence of specific protective responses, activated by a low-intracellular [Mg++], at times, (particularly post head- injury), and used as a metabolic ‘alarm-signal’. These ‘fail-safe’ systems would also help regulate, buffer, and restore cell [Mg++], and as Li+ mimics a low cell [Mg++] level, activating these pre-existing systems provides the underlying basis of Lithium’s therapeutic effects. The ‘fail-safe’-model postulates the existence of pre-programmed biochemical responses, adapted to provide protection against t.b.i., mechanical brain injury; involving the activation of pathways sensitive to a low-free cell [Mg++], these appear to be ‘parasitically’ utilised by Lithium to generate its therapeutic effects. These systems would underpin neuronal cell protection, and provide a key biochemical mechanism for stabilising mood, and providing intrinsic mental and cellular resilience.

Neural Mechanisms | Neurology | Neuropsychiatry | Psychiatry | Neurological Disorders Neuroscience | Bipolar Disorders Cognitive Neuroscience | Alzheimers Disease | Depression | Psychotherapy
Chair
Co-Chair
Speaker
  • 1
    Exploring the basis of neuroregeneration: identification of key molecules with proteomics and functional assays in the mammalian spinal cord
    Time: 12:05-12:35
    Speaker
    Miranda Mladinic
    University of Rijeka, Croatia
    Croatia
    Biography

    Miranda Mladinic has completed her PhD in 1998 at SISSA, Trieste, Italy. She is the professor at the department of biotechnology of the University of Rijeka, Croatia and the head of the unit for molecular and systemic biomedicine. She is also a member of the council of the senate to the University of Rijeka and to the council for scientific research of the University of Rijeka. She is the member of the evaluation committee of the Croatian Science foundation in the field of natural sciences – biology. She has over 30 publications that have been cited over 580 times, and her publication H-index is 17 and has been serving as reviewer of reputed journals and International scientific foundations.

    Abstract

    One of the major challenges of modern biology concerns the inability of the adult mammalian central nervous system (CNS) to regenerate and repair itself after injury. Unlike the situation in adult mammals, lower vertebrates, such as fish and amphibians, and embryonal higher vertebrates can regenerate significant portion of their CNS. It is poorly understood why this potential is lost with evolution and development and becomes very limited in adult mammals. A preferred model to study and reveal the cellular and molecular basis of this loss is neonatal opossum (Monodelphis domestica). Opossums are marsupials that are born at very immature stage with unique possibility to successfully regenerate spinal cord after injury in the first two weeks of their life and thus offer an exceptional opportunity to study neuronal regeneration. We are analyzing the proteoms of the spinal tissue of the opossums of different age, looking for the molecules associated with regenerative axon growth and testing their functional role in neuronal regeneration using in vitro intact spinal cord cultures and advanced imaging. In parallel, we are developing opossum primary spinal cell cultures made from the animals of different age, to reveal dissimilarities in their cellular content (giving focus on stem cells) and metabolic characteristics related to regeneration. Our results are giving new insights into neuronal regeneration in mammals, but also provide candidate targets for future novel therapeutic interventions for neurodegenerative disorders.

  • Ablative functional neurosurgery in the treatment of movement disorders : CIREN experience, Cuba
    Time: 12:35-13:05
    Speaker
    Nelson Quintanal Cordero
    International Center of Neurological Restauration
    Cuba
    Biography

    Nelson Quintanal Cordero is a head and board member of neurosurgery at International Center of Neurological Restoration. (CIREN) Havana, Cuba.

    Abstract

    Introduction Effectiveness and safety of ablative surgery for movement disorders depend, among others, on the location of lesions in the nuclear regions of interest and the volume of these lesions. Material and Methods We describe the methods of radiofrequency ablation that are developed in the CIREN in the approach to the subthalamic nucleus (STN), internal globus pallidus (GPi) and ventralis intermedius nucleus (VIM) of the thalamus, performed on patients diagnosed with Parkinson's disease (PD), dystonia and essential tremor. These methods efficacy and safety were evaluated by clinical findings and by checking postoperative lesions (location, shape and dimensions) by magnetic resonance images (MRI). Results A total of 1103 ablative surgeries were performed in 1015 patients over a twenty- year period, divided into 425 subthalamotomies, 549 pallidotomies and 129 VIM thalamotomies. The anatomical location method and electrophysiological confirmation were sufficient to perform the procedure. The subthalamic nucleus lesion was effective in controlling the cardinal manifestations of PD with predominantly contralateral and axial effects. The pallidotomy in PD was effective mainly for the control of rigidity and dyskinesias. Bilateral Pallidotomy in a single surgical time is effective in patients with generalized dystonia. VIM thalamotomy has good effect in the treatment of essential tremor and in PD with predominance of tremor.

  • Adaptive sports medicine: Uniqueness and challenges of providing specialty care
    Time: 15:00-15:30
    Speaker
    Kenneth Lee
    Clement J Zablocki Veterans Affairs Medical Center
    USA
    Biography

    Kenneth Lee is manager and the Milwaukee Eagles are one of the nation’s premier squads. Every year their Eagles host a home wheelchair lacrosse tournament at the Ozaukee Ice Center. Milwaukee Eagles is led by Kenneth Lee and Marquette University’s lacrosse team.

    Abstract

    At one point in our lives we all played catch, kicked a ball, ran a race, or played in an organized sport. Sports are ingrained in our society and are part of being a human. Adaptive sports medicine includes the practice of disability medicine with sports medicine and incorporates the knowledge of the specific sports with their pattern of injuries and specialized equipment. In general, able body sports medicine works with healthy individuals who succumb to a temporary illness and/or acute injury. The athletes in this field tend to be in great physical condition with minimal underlying medical problems. Adaptive sports medicine athletes have significant underlying medical or traumatic conditions, and complications related to the individual disability. There are also unique injuries related to the adaptive and assistive equipment used in to compete. All adaptive sports athletes have baseline medical status that defines their physical disability such as SCI, amputation, poly-trauma, and traumatic brain injury. Each condition is unique and requires understanding by the individual athlete as well the healthcare provider. For example, an athlete with a spinal cord injury would require special attention to the skin care below the level of injury, especially in tight fitting adaptive equipment and require periodic pressure releases in endurance sports events. Understanding SCI and the potential for skin complications along with equipment needs can prevent devastating pressure injuries leading to potentially prolonged recovery. An example of the need for the understanding of unique complications of an underlying disability is autonomic dysreflexia. Autonomic dysreflexia (AD) is a medical emergency that occurs in patients with SCI above T6. It causes an imbalanced reflex sympathetic discharge, and if unrecognized, or left untreated, can lead to potentially life-threatening hypertension, seizures, pulmonary edema, myocardial infarction, cerebral hemorrhage and death. Athletes involved in adaptive sports have conditions that can put them at higher risk than able body athletes. Many athletes with SCI have osteoporosis in their domain.

  • Towards augmented cognition
    Speaker
    Alice Marascu
    Nokia Bell Labs
    Ireland
    Biography

    Alice Marascu is a senior research scientist at Nokia Bell Labs. Previously, she was a research scientist at IBM Research-Ireland, and held post-doctoral research roles at University of Trento-Italy, and INRIA Rennes Bretagne Atlantique-France. Her research spans natural language processing, large scale streaming data processing, large scale complex pattern recognition and mining, time series analysis. She has given multiple talks to industrial and academic audiences and published results in main conferences in the areas of big data, data mining, machine learning, query answering (VLDB, PVLDB, SIGMOD, Big Data Conference, etc.).

    Abstract

    Technological advances are contributing like never before to the human innate desire for cognitive expansion. Understanding how we interact and communicate with our surroundings is crucial for pushing the boundaries of content assimilation. Neuroscience latest results open the door to understanding the human communication at more complex levels and more medical results are coming today to support a body holistic communication system. By modelling and monitoring hidden communication indictors, we aim to understand the cognitive best achievable performances. The large collections of big data and information available today at just 1-click away could become thus more cognitively “digestible”. Human cognition can be mainly expanded at three levels: flow of data to which the human body is exposed, internal cognitive model that is processing the data and retaining the gems, and, finally, the visible behaviors that are materializing the internal decisions. In this work, we will primarily focus on the first two levels and explore new achievable cognition insights by mixing neuroscience knowledge with computational models from the computer science domain.

Day 2

KEYNOTE SPEAKERS
  • Innovated micro-surgical suction and irragtions neuro – surgical dissecting forceps with “bipolar capabilities”

    University of Alexandria
    Egypt
    Biography

    Mohamed Ahmed Fahmy Zeid is a founder and chair of Brain & Skull Egyptian Society, full professor of neurosurgery, Alexandria University, Egypt. He is a specialized professor of neurosurgical department.

    Abstract

    Abstract Objective: The operating surgeons usually using the dissection forceps while the assistants continuously keeping the surgical field relatively clean by irrigation and suction through suction tube and another one for irrigation which might lead to “crowded“ or busy traffic operative field by many instruments under magnification. Methods: Our innovated forceps use the two limps of the forceps for two separate functions, one for irrigation, while the other limp for suction by using a tube inside each of both, This tube end separately in the back of that forceps, however from the two limps & tubes one of them is attached to the disposable polyethylene channel tube to the finely granulated power suction apparatus. While the other tube at the back end of that forceps is attached to the line of infusion control irrigation which could be control the speed of the flow of saline irrigation out to the field of surgery. So, we could control the power of both functions accurate and separately. Result: We have already made the pro-type of that forceps which have been used for experimental surgery in animal & also, recently have been used in one of our patient, for that particular case a video-clip was inserted. Conclusions: So, the use of the single instrument “The Forceps” for dissection, irrigation and suction actually facilitate micro- surgical operation

  • Concussion update: 2019

    Institute for Clinical Neurosciences
    USA
    Biography

    Dr. Bob Gant is a board-certified Clinical Neuropsychologist with extensive professional experience as a treating and Forensic Neuropsychologist, including the assessment of and treatment of brain injury and PTSD. He completed a clinical internship at the University of Kansas Medical Center and is the past President of section II of the APA Division of Clinical Psychology. He is a licensed Psychologist in two states (Colorado and Texas) in the United States. He is on the board of the American Board of Professional Neuropsychology (ABN) and Director of an approved Residency program in Clinical Neuropsychology (ACPN) in Boulder Colorado and Dallas, Texas.

    Abstract

    This presentation will provide an update on the status of concussion comma including a discussion of issues such as recovery time, the impact on brain functioning & treatment and rehabilitation issues. This is an important topic as clinicians and researchers attempt to understand sports related head injuries, traumatic head injuries associated with violence and war, and head injuries suffered as part of life including those sustained in household accidents and motor vehicle accidents. A discussion of predictors of clinical recovery will be included including predictors for return to work and school following a concussion. Recommendations will be discussed including recommendations for treatment, exercise, and medical intervention which might facilitate recovery. It is hoped that the attendee we’ll obtain a clear understanding of the status of concussion research and treatment as a result of this overview.

Neuropathic Pain | Cognitive Neuroscience | Autism | Neurology | Neuro Immunology | Traumatic Brain Injury | Neurodiagnostic studies | Multiple Sclerosis | Mental Health | Neurosurgery | Neuroprotective Measures
Chair
Co-Chair
  • Allied Academies Neuroscience Congress 2019 Co-Chair Speaker Bob Gant photo
    Bob Gant
    Institute for Clinical Neurosciences
    USA
Speaker
  • Strategy of petrous meningioma surgery
    Speaker
    Mohamed Fahmy Zeid
    Alexandria University
    Egypt
    Biography

    Mohamed Fahmy Zeid completed Master of General Surgery in 1988 and pursued his fellowship in the department of Neurosurgery in 1994. He earned doctorate degree in Neurological surgery in 1994. He was the House officer in Ministry of Health Hospitals and Alexandria university Hospitals for one year from 1983 to 1984. He worked as physician in the Ministry of Health Hospitals from 1984 to 1987. He is Registrar of Neurosurgery in private hospital from 1987 to 1988. He is Assistant lecturer of Neurosurgical department of Alexandria University Hospitals from 1988 to 1994. He is chief consultant of Neurosurgery in Saqr Hospitals, UAE from 2000 to 2003.He visited to Neurological surgery department, Royal College of Medicine,London in 2001. He is working as Professor of Neurosurgery department at Alexandria University from 2010 to till date and he is the Founder & President of Brain & Skull Egyptian Society from Last October 2017.

    Abstract

    Objective Petrous meningioma is benign lesions; their total surgical excision is the only method for complete cure. However their excisions are confronted by deep location and critical anatomical relation and exact site of origin from the petrous bone. This study was conducted to plan a surgical strategy based on the site of attachment of the lesion in the petrous bone. Methods Twenty five (25) were studied pre-operatively by neuro-imaging especially magnetic resonance imaging (MRI). To classify the types of petrous meningioma all cases were studied operatively for the extent of the tumor removal while clinical status and the follow up and histopathological verification were evaluated. Results Radical surgical removal was achieved in eighteen patients (72%), subtotal removal in four cases (16%) and incomplete removal in another three cases (12%). Conclusion Complete surgical excision of the petrous meningioma can be planned pre-operatively depending on the exact site of the attachment to the petrous bone. There were four different zones on the surface of petrous bone on which different type of surgical approach can be used to achieve a better result as regards the safety of the patient and the extend of the excions of the petrous meningioma’s.

  • Investigating the anti-inflammatory effects of a novel nootropic in glial cells exposed to anti-retroviral therapy
    Speaker
    Helena Isla Magrané
    Brighton University
    United Kingdom
    Biography

    Helena Isla Magrane is a Biothechnologist who performed a master research bioscience in Brighton University (UK). Focused her master thesis on neuroscience area. Gained a lot of experience on reasearch, investigated the anti-inflammatoey effects of a novel nootropic drug in glial cells exposed to anti-retroviral therapy, carried out the project in collaboration with Imperial College of London. potential problem solver and very passioned on her work as she love science.

    Abstract

    Neuroinflammation is a process that can be observed not only in neurodegenerative diseases but also as a result of infection alterations in the brain. The infection agent, or the drugs used to treat the pathology, can lead to neuroinflammation. The neuroinflammatory effects of different drugs used to treat HIV have not been investigated yet. The aim of this project is to test the inflammatory effects of anti retroviral drugs used to treat HIV patients in brain cell cultures. Once the cause of the inflammation is known, the decision on which drug to use, for each particular case, will be easier to make. In the case of patients with neuroinflammation, some anti-retroviral drugs – expected to be less inflammatory – can be used. Furthermore, a nootropic drug was tested. This could play an important role in helping to cope with the inflammation. To test the inflammatory effects of the drugs, we used microglia and astrocyte in vitro models. Glial cells and astrocytes can secrete or respond with a variety of cytokines. IL 1 ?, IL-6 and TNF-?, are cytokines used as markers for inflammation. In this study, the ability of mixed glial cells and astrocytes to secrete IL-1 ?, IL-6 and TNF-? in response to three anti-retroviral drugs (maraviroc, efavirenz and rilpivirine) has been examined. Loss of memory is one of the consequences in later stages in HIV. Sunifiram, a novel nootropic drug, is believed to help with inflammation and to improve cognition. The pro inflammatory or anti-inflammatory effect of Sunifiram on astrocyte cultures, combined with the anti-inflammatory drug treatments, was tested.

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