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Biography

Hiroki Konno has completed his PhD from Tokyo Institute of Technology (Tokyo Tech) in 2002 and Post-doctoral studies from Tokyo Tech. In 2006, he joined chemical resources laboratory, Tokyo Tech, as an Assistant Professor. In the above period, he has studied regulation mechanism of rotary motor, ATP synthase, with biochemical and biophysical methods. Since November 2011, he has been with the Imaging Research Division of Bio-AFM Frontier Research Center, Kanazawa University, where he is currently an Associate Professor. His current research interests include observing protein molecule in dynamic action with HS-AFM.

Abstract

Peroxiredoxin (Prx) is an ubiquitous antioxidant enzyme that reduces reactive oxygen species (ROS) such as hydrogen peroxide, organic peroxide and peroxynitrite. Prxs are classified into typical 2-Cys Prx, atypical 2-Cys Prx and 1-Cys Prx based on the number of cysteine residues and the catalytic mechanisms for their peroxidase activity. The function of 2-Cys peroxiredoxins (2Cys-Prxs) can be converted alternatively from peroxidases to molecular chaperones. This conversion has been reported to occur by the formation of high molecular weight (HMW) complexes upon overoxidation of or ATP/ADP binding to 2-Cys Prxs that appear in electron micrographs as spheres, decameric rings, double-stacked decamers or further stacked filaments. However, the entity responsible for the chaperone function is under debate. We employed the high-speed atomic force microscopy (HS-AFM) to investigate correlation between structure of HMW complex of human PrxII (hPrxII) and its chaperone activity. By the HS-AFM observation, we found that upon binding to phospholipids dimeric human 2-Cys PrxII (hPrxII) is assembled to small oligomers with full chaperone and null peroxidase activities. Spherical HMW complexes are formed, only when phospholipids is bound to overoxidized or ATP/ADP-bound hPrxII. The spherical HMW complexes are lipid vesicles covered with hPrxII oligomers arranged in a hexagonal lattice pattern. Thus, these lipids can be supplied by increased membrane trafficking under oxidative stress, are essential for the structural and functional switch of hPrxII and possibly most 2-Cys Prxs.

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All cancellations or modifications of registration must be made in writing to biotechnology@alliedconferences.org

Cancellation Policy

If  Allied Academies cancels this event for any reason, you will receive a credit for 100% of the registration fee paid. You may use this credit for another Allied Academies event which must occur within one year from the date of cancellation.

Postponement

If Allied Academies Ltd postpones an event for any reason and you are unable or unwilling to attend on rescheduled dates, you will receive a credit for 100% of the registration fee paid. You may use this credit for another Allied Academies event which must occur within one year from the date of postponement.

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All fully paid registrations are transferable to other persons from the same organization, if registered person is unable to attend the event. Transfers must be made by the registered person in writing to biotechnology@alliedconferences.org. Details must be included the full name of replacement person, their title, contact phone number and email address. All other registration details will be assigned to the new person unless otherwise specified.

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However, Registration cannot be transferred if it is intimated within 14 days of respective conference.
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Allied Academies will not directly contact embassies and consulates on behalf of visa applicants. All delegates or invitees should apply for Business Visa only.

Important note for failed visa applications: Visa issues cannot come under the consideration of cancellation policy of Allied Academies, including the inability to obtain a visa.

Refund Policy:

If the registrant is unable to attend, and is not in a position to transfer his/her participation to another person or event, then the following refund arrangements apply:

Keeping in view of advance payments towards Venue, Printing, Shipping, Hotels and other overheads, we had to keep Refund Policy is as following slabs-
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Accommodation Providers (Hotels) have their own cancellation policies, and they generally apply when cancellations are made less than 30 days prior to arrival. Please contact us as soon as possible, if you wish to cancel or amend your accommodation. Allied Academies Ltd will advise the cancellation policy of your accommodation provider, prior to cancelling or amending your booking, to ensure you are fully aware of any non-refundable deposits.


Authorization Policy

Cancellation, Postponement and Transfer of Registration

All cancellations or modifications of registration must be made in writing to biotechnology@alliedconferences.org

Cancellation Policy

If  Allied Academies cancels this event for any reason, you will receive a credit for 100% of the registration fee paid. You may use this credit for another Allied Academies event which must occur within one year from the date of cancellation.

Postponement

If Allied Academies Ltd postpones an event for any reason and you are unable or unwilling to attend on rescheduled dates, you will receive a credit for 100% of the registration fee paid. You may use this credit for another Allied Academies event which must occur within one year from the date of postponement.

Transfer of registration

All fully paid registrations are transferable to other persons from the same organization, if registered person is unable to attend the event. Transfers must be made by the registered person in writing to biotechnology@alliedconferences.org. Details must be included the full name of replacement person, their title, contact phone number and email address. All other registration details will be assigned to the new person unless otherwise specified.

Registration can be transferred to one conference to another conference of Allied Academies if the person is unable to attend one of conferences.

However, Registration cannot be transferred if it is intimated within 14 days of respective conference.
The transferred registrations will not be eligible for Refund.

Visa Information

Keeping in view of increased security measures, we would like to request all the participants to apply for Visa as soon as possible.

Allied Academies will not directly contact embassies and consulates on behalf of visa applicants. All delegates or invitees should apply for Business Visa only.

Important note for failed visa applications: Visa issues cannot come under the consideration of cancellation policy of Allied Academies, including the inability to obtain a visa.

Refund Policy:

If the registrant is unable to attend, and is not in a position to transfer his/her participation to another person or event, then the following refund arrangements apply:

Keeping in view of advance payments towards Venue, Printing, Shipping, Hotels and other overheads, we had to keep Refund Policy is as following slabs-
  • Before 60 days of the conference: Eligible for Full Refund less $150 service Fee
  • Within 60-30 days of Conference: Eligible for 40% of payment Refund
  • Within 45 days of Conference: Not eligible for Refund

Accommodation Cancellation Policy:

Accommodation Providers (Hotels) have their own cancellation policies, and they generally apply when cancellations are made less than 30 days prior to arrival. Please contact us as soon as possible, if you wish to cancel or amend your accommodation. Allied Academies Ltd will advise the cancellation policy of your accommodation provider, prior to cancelling or amending your booking, to ensure you are fully aware of any non-refundable deposits.

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