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Biography

Goetz RA Ehrhardt has completed his PhD at the University of British Columbia and continued his training as Post-doctoral fellow in the laboratory of Dr. Max D Cooper at Emory University in Atlanta, GA. In 2011, he was recruited to the Department of Immunology at the University of Toronto. His laboratory focuses on mechanisms governing the regulation of human memory B cell responses and on the use of the non-conventional VLR antibody system of jawless vertebrates for biomarker discovery purposes.

Abstract

Monoclonal antibodies are widely used reagents in biomedical research as well as in clinical applications. However, tolerogenic and structural constraints limit the antibody repertoire. In contrast to conventional antibodies, the recently identified variable lymphocyte receptor (VLR) antibodies of the evolutionarily distant jawless vertebrates utilize the ?-sheet forming leucine-rich repeat (LRR) as basic structural unit. We hypothesize that the unique origins and radically distinct protein architecture will allow VLR antibodies to bind antigens, which conventional antibodies cannot readily recognize for tolerogenic or structural constraints. Memory B cells (Bmem) and plasma cells (PC) are tasked with providing long lasting humoral protection to re-encountered pathogens. However, no conventional antibodies exist that specifically detect these cell populations. In an effort to identify novel biomarkers uniquely expressed on Bmem and PC, we developed a method to generate monoclonal VLR antibodies to cell surface antigens. We isolated panels of monoclonal VLR antibodies binding specifically to human Bmem and PC. Flow cytometric analysis of VLR antibody binding to cell lines and primary human cells from blood, tonsil, spleen and bone marrow revealed binding patterns that are inconsistent with those of any conventional antibody, suggesting that the monoclonal VLR antibodies recognize novel antigens. Interestingly, we observed greatly increased VLR antibody binding to memory B cell populations in blood of individuals diagnosed with the autoimmune disorders Systemic Lupus Erythematosus (SLE) and Multiple Sclerosis (MS). Our data indicate that monoclonal VLR antibodies hold promise as novel reagents with a wide range of application potential in basic and clinical research.

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Cancellation, Postponement and Transfer of Registration

All cancellations or modifications of registration must be made in writing to biotechnology@alliedconferences.org

Cancellation Policy

If  Allied Academies cancels this event for any reason, you will receive a credit for 100% of the registration fee paid. You may use this credit for another Allied Academies event which must occur within one year from the date of cancellation.

Postponement

If Allied Academies Ltd postpones an event for any reason and you are unable or unwilling to attend on rescheduled dates, you will receive a credit for 100% of the registration fee paid. You may use this credit for another Allied Academies event which must occur within one year from the date of postponement.

Transfer of registration

All fully paid registrations are transferable to other persons from the same organization, if registered person is unable to attend the event. Transfers must be made by the registered person in writing to biotechnology@alliedconferences.org. Details must be included the full name of replacement person, their title, contact phone number and email address. All other registration details will be assigned to the new person unless otherwise specified.

Registration can be transferred to one conference to another conference of Allied Academies if the person is unable to attend one of conferences.

However, Registration cannot be transferred if it is intimated within 14 days of respective conference.
The transferred registrations will not be eligible for Refund.

Visa Information

Keeping in view of increased security measures, we would like to request all the participants to apply for Visa as soon as possible.

Allied Academies will not directly contact embassies and consulates on behalf of visa applicants. All delegates or invitees should apply for Business Visa only.

Important note for failed visa applications: Visa issues cannot come under the consideration of cancellation policy of Allied Academies, including the inability to obtain a visa.

Refund Policy:

If the registrant is unable to attend, and is not in a position to transfer his/her participation to another person or event, then the following refund arrangements apply:

Keeping in view of advance payments towards Venue, Printing, Shipping, Hotels and other overheads, we had to keep Refund Policy is as following slabs-
  • Before 60 days of the conference: Eligible for Full Refund less $150 service Fee
  • Within 60-46 days of Conference: Eligible for 40% of payment Refund
  • Within 45 days of Conference: Not eligible for Refund

Accommodation Cancellation Policy:

Accommodation Providers (Hotels) have their own cancellation policies, and they generally apply when cancellations are made less than 30 days prior to arrival. Please contact us as soon as possible, if you wish to cancel or amend your accommodation. Allied Academies Ltd will advise the cancellation policy of your accommodation provider, prior to cancelling or amending your booking, to ensure you are fully aware of any non-refundable deposits.


Authorization Policy

Cancellation, Postponement and Transfer of Registration

All cancellations or modifications of registration must be made in writing to biotechnology@alliedconferences.org

Cancellation Policy

If  Allied Academies cancels this event for any reason, you will receive a credit for 100% of the registration fee paid. You may use this credit for another Allied Academies event which must occur within one year from the date of cancellation.

Postponement

If Allied Academies Ltd postpones an event for any reason and you are unable or unwilling to attend on rescheduled dates, you will receive a credit for 100% of the registration fee paid. You may use this credit for another Allied Academies event which must occur within one year from the date of postponement.

Transfer of registration

All fully paid registrations are transferable to other persons from the same organization, if registered person is unable to attend the event. Transfers must be made by the registered person in writing to biotechnology@alliedconferences.org. Details must be included the full name of replacement person, their title, contact phone number and email address. All other registration details will be assigned to the new person unless otherwise specified.

Registration can be transferred to one conference to another conference of Allied Academies if the person is unable to attend one of conferences.

However, Registration cannot be transferred if it is intimated within 14 days of respective conference.
The transferred registrations will not be eligible for Refund.

Visa Information

Keeping in view of increased security measures, we would like to request all the participants to apply for Visa as soon as possible.

Allied Academies will not directly contact embassies and consulates on behalf of visa applicants. All delegates or invitees should apply for Business Visa only.

Important note for failed visa applications: Visa issues cannot come under the consideration of cancellation policy of Allied Academies, including the inability to obtain a visa.

Refund Policy:

If the registrant is unable to attend, and is not in a position to transfer his/her participation to another person or event, then the following refund arrangements apply:

Keeping in view of advance payments towards Venue, Printing, Shipping, Hotels and other overheads, we had to keep Refund Policy is as following slabs-
  • Before 60 days of the conference: Eligible for Full Refund less $150 service Fee
  • Within 60-30 days of Conference: Eligible for 40% of payment Refund
  • Within 45 days of Conference: Not eligible for Refund

Accommodation Cancellation Policy:

Accommodation Providers (Hotels) have their own cancellation policies, and they generally apply when cancellations are made less than 30 days prior to arrival. Please contact us as soon as possible, if you wish to cancel or amend your accommodation. Allied Academies Ltd will advise the cancellation policy of your accommodation provider, prior to cancelling or amending your booking, to ensure you are fully aware of any non-refundable deposits.

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