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Biography

Liu Canying has completed her PhD at the age of 28 years from Huazhong Agricultural University College of Veterinary Medicine. She has just graduated and been the lecturer of Foshan University Department of Veterinary Medicine for about one year. She has published 4 papers in famous journals. She mainly performed research projects about the comparative genomic and pathogenicity analyses of bacteria, immunogenicity analyse of outer membrane proteins of bacteria.

Abstract

Antimicrobial peptides (AMPs) are regarded as host defense peptides which processes bactericidal, and they have also been reported to have immunomodulatory function in many tissues. However, their role in the mammalian ovary is unknown. We have previously found that beta defensin 2 (BD2) and beta defensin 3 (BD3) are expressed in granulosa cells and cumulus cells during porcine ovarian follicular development and cumulus-oocyte-complex maturation. We hypothesized that these antimicrobial peptides are involved in the regulation of follicular development in ovaries. Granulosa cells were isolated from small (1-3 mm in diameter) and large (4-8 mm in diameter) porcine follicles and cultured in the absence and presence of 1, 10, and 50 ?g/ml of BD2, and BD3. After 24 hours of treatment, cell numbers were counted using an automated cell counter. It was found that while BD2 appears to have no effect, BD3 stimulated granulosa cell proliferation in a dose dependent manner (p < 0.05). This effect is also dependent on the stage of follicular development, as it is effective on granulosa cell from small but not large follicles. In addition, transwell cell migration assay revealed that in the presence of BD3 (10 ?g/ml), a 2.5 fold increase in cell migration was achieved. To further study the potential pathway involved in BD3 induced cell proliferation; western blots were performed to determine the ratio of phosphorylated- and non-phosphorylated-ERK1/2. It was found that BD3 significantly increased the phosphorylated- ERK1/2 ratio. Moreover, U0126, the specific ERK1/2 phosphorylation inhibitor, suppressed BD3 induced ERK1/2 phosphorylation and proliferation, suggesting that BD3 may stimulate granulosa cell proliferation via activating the MAPK pathway. Our data suggests that antimicrobial peptides may play a physiological role, in addition to being the traditionally recognized immune-defense mechanism, in regulating follicular development in the mammalian ovary.

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Cancellation, Postponement and Transfer of Registration

All cancellations or modifications of registration must be made in writing to biotechnology@alliedconferences.org

Cancellation Policy

If  Allied Academies cancels this event for any reason, you will receive a credit for 100% of the registration fee paid. You may use this credit for another Allied Academies event which must occur within one year from the date of cancellation.

Postponement

If Allied Academies Ltd postpones an event for any reason and you are unable or unwilling to attend on rescheduled dates, you will receive a credit for 100% of the registration fee paid. You may use this credit for another Allied Academies event which must occur within one year from the date of postponement.

Transfer of registration

All fully paid registrations are transferable to other persons from the same organization, if registered person is unable to attend the event. Transfers must be made by the registered person in writing to biotechnology@alliedconferences.org. Details must be included the full name of replacement person, their title, contact phone number and email address. All other registration details will be assigned to the new person unless otherwise specified.

Registration can be transferred to one conference to another conference of Allied Academies if the person is unable to attend one of conferences.

However, Registration cannot be transferred if it is intimated within 14 days of respective conference.
The transferred registrations will not be eligible for Refund.

Visa Information

Keeping in view of increased security measures, we would like to request all the participants to apply for Visa as soon as possible.

Allied Academies will not directly contact embassies and consulates on behalf of visa applicants. All delegates or invitees should apply for Business Visa only.

Important note for failed visa applications: Visa issues cannot come under the consideration of cancellation policy of Allied Academies, including the inability to obtain a visa.

Refund Policy:

If the registrant is unable to attend, and is not in a position to transfer his/her participation to another person or event, then the following refund arrangements apply:

Keeping in view of advance payments towards Venue, Printing, Shipping, Hotels and other overheads, we had to keep Refund Policy is as following slabs-
  • Before 60 days of the conference: Eligible for Full Refund less $150 service Fee
  • Within 60-30 days of Conference: Eligible for 40% of payment Refund
  • Within 45 days of Conference: Not eligible for Refund

Accommodation Cancellation Policy:

Accommodation Providers (Hotels) have their own cancellation policies, and they generally apply when cancellations are made less than 30 days prior to arrival. Please contact us as soon as possible, if you wish to cancel or amend your accommodation. Allied Academies Ltd will advise the cancellation policy of your accommodation provider, prior to cancelling or amending your booking, to ensure you are fully aware of any non-refundable deposits.

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