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Biography

Ashok Kumar is a Professor in the Department of Pathology and Laboratory Medicine and in the Department of Biochemistry, Microbiology and Immunology at the University of Ottawa, Ontario, Canada. He is also a Senior Scientist at the Children’s Hospital of Eastern Ontario, Research Institute, Ottawa, ON, Canada. His main research interests are in the field of HIV immunopathogenesis, induction and regulation of apoptosis in HIV-infected human macrophages, regulation of T helper cytokines in health and disease and Toll-like receptor signaling in healthy and HIV-infected innate immune cells such as human macrophages and macrophage subsets.

Abstract

To eradicate HIV in individuals on ART (antiretroviral therapy), it is imperative to eliminate both CD4+ T cells and myeloid cell reservoirs. Most research to-date has focused on eliminating the latent reservoir of CD4+ T cells. However, information regarding the potential elimination of HIV-infected macrophages is lacking. We have previously demonstrated that resistance of monocyte-derived macrophages (MDMs) to Vpr-induced effects was attributed to inhibitors of apoptosis (c-IAP-2) expression. These results suggest that strategies based on suppressing IAP-1/2 by its specific inhibitor, smac mimetics (SM) may be useful in killing HIV-infected macrophages. Our results show that SM do not affect uninfected normal MDMs but selectively kill in vitro HIV-infected macrophages, and macrophages derived from the HIV-infected patients. We also show that by using HIV-GFP strain, SM induced apoptosis of HIV- infected macrophages. In addition, HIV-chronically infected U1 cells were highly susceptible to SM-induced apoptosis in contrast to its corresponding U937 cells. We have investigated the molecular mechanism governing selective apoptosis of HIV-infected macrophages by SM. Our results show that SM induced macrophage cell death through apoptosis and not through necroptosis. Furthermore, SM-induced apoptosis in HIV-infected macrophages is not mediated through TNF-?. In addition, in vitro HIV infection inhibits expression of RIP-1, RIP-3 and TRAF-1 and bid. Inhibition of Rip-1 by its inhibitor, necrostatin, induced cell death in normal macrophages following treatment with SM suggesting a key role for Rip-1 in SM-induced killing of HIV-infected macrophages. Overall, the results suggest that inhibitions of IAPs could be a potential strategy to selectively kill HIV-infected macrophages.

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All cancellations or modifications of registration must be made in writing to biotechnology@alliedconferences.org

Cancellation Policy

If  Allied Academies cancels this event for any reason, you will receive a credit for 100% of the registration fee paid. You may use this credit for another Allied Academies event which must occur within one year from the date of cancellation.

Postponement

If Allied Academies Ltd postpones an event for any reason and you are unable or unwilling to attend on rescheduled dates, you will receive a credit for 100% of the registration fee paid. You may use this credit for another Allied Academies event which must occur within one year from the date of postponement.

Transfer of registration

All fully paid registrations are transferable to other persons from the same organization, if registered person is unable to attend the event. Transfers must be made by the registered person in writing to biotechnology@alliedconferences.org. Details must be included the full name of replacement person, their title, contact phone number and email address. All other registration details will be assigned to the new person unless otherwise specified.

Registration can be transferred to one conference to another conference of Allied Academies if the person is unable to attend one of conferences.

However, Registration cannot be transferred if it is intimated within 14 days of respective conference.
The transferred registrations will not be eligible for Refund.

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Keeping in view of increased security measures, we would like to request all the participants to apply for Visa as soon as possible.

Allied Academies will not directly contact embassies and consulates on behalf of visa applicants. All delegates or invitees should apply for Business Visa only.

Important note for failed visa applications: Visa issues cannot come under the consideration of cancellation policy of Allied Academies, including the inability to obtain a visa.

Refund Policy:

If the registrant is unable to attend, and is not in a position to transfer his/her participation to another person or event, then the following refund arrangements apply:

Keeping in view of advance payments towards Venue, Printing, Shipping, Hotels and other overheads, we had to keep Refund Policy is as following slabs-
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Accommodation Cancellation Policy:

Accommodation Providers (Hotels) have their own cancellation policies, and they generally apply when cancellations are made less than 30 days prior to arrival. Please contact us as soon as possible, if you wish to cancel or amend your accommodation. Allied Academies Ltd will advise the cancellation policy of your accommodation provider, prior to cancelling or amending your booking, to ensure you are fully aware of any non-refundable deposits.


Authorization Policy

Cancellation, Postponement and Transfer of Registration

All cancellations or modifications of registration must be made in writing to biotechnology@alliedconferences.org

Cancellation Policy

If  Allied Academies cancels this event for any reason, you will receive a credit for 100% of the registration fee paid. You may use this credit for another Allied Academies event which must occur within one year from the date of cancellation.

Postponement

If Allied Academies Ltd postpones an event for any reason and you are unable or unwilling to attend on rescheduled dates, you will receive a credit for 100% of the registration fee paid. You may use this credit for another Allied Academies event which must occur within one year from the date of postponement.

Transfer of registration

All fully paid registrations are transferable to other persons from the same organization, if registered person is unable to attend the event. Transfers must be made by the registered person in writing to biotechnology@alliedconferences.org. Details must be included the full name of replacement person, their title, contact phone number and email address. All other registration details will be assigned to the new person unless otherwise specified.

Registration can be transferred to one conference to another conference of Allied Academies if the person is unable to attend one of conferences.

However, Registration cannot be transferred if it is intimated within 14 days of respective conference.
The transferred registrations will not be eligible for Refund.

Visa Information

Keeping in view of increased security measures, we would like to request all the participants to apply for Visa as soon as possible.

Allied Academies will not directly contact embassies and consulates on behalf of visa applicants. All delegates or invitees should apply for Business Visa only.

Important note for failed visa applications: Visa issues cannot come under the consideration of cancellation policy of Allied Academies, including the inability to obtain a visa.

Refund Policy:

If the registrant is unable to attend, and is not in a position to transfer his/her participation to another person or event, then the following refund arrangements apply:

Keeping in view of advance payments towards Venue, Printing, Shipping, Hotels and other overheads, we had to keep Refund Policy is as following slabs-
  • Before 60 days of the conference: Eligible for Full Refund less $150 service Fee
  • Within 60-30 days of Conference: Eligible for 40% of payment Refund
  • Within 45 days of Conference: Not eligible for Refund

Accommodation Cancellation Policy:

Accommodation Providers (Hotels) have their own cancellation policies, and they generally apply when cancellations are made less than 30 days prior to arrival. Please contact us as soon as possible, if you wish to cancel or amend your accommodation. Allied Academies Ltd will advise the cancellation policy of your accommodation provider, prior to cancelling or amending your booking, to ensure you are fully aware of any non-refundable deposits.

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